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Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 421-430 doi: 10.1007/s11684-015-0424-9

Abstract: This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoidorgan maintenance and discusses the mechanisms that regulate PDPN expression related to its function

Keywords： podoplanin     CLEC-2     Prox1     O-glycosylation     lymphatic vascular development and maintenance     lymphoidorgan homeostasis    

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Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 374-386 doi: 10.1007/s11684-018-0652-x

Abstract:

A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiation, is capable of regulating cell proliferation, survival and differentiation, and is often upregulated in multiple types of tumors. Due to their ability to promote self-renewal, Id proteins have been considered as oncogenes, and potential therapeutic targets in cancer models. On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of Burkitt’s lymphoma in humans, and hepatosplenic and innate-like T cell lymphomas in mice. The contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumor outcomes are still not well understood. In this review, we explore the roles of Id proteins in lymphocyte development and tumorigenesis, particularly with respect to inhibition of their canonical DNA binding partners known as E proteins. Transcriptional regulation by E proteins, and their antagonism by Id proteins, act as gatekeepers to ensure appropriate lymphocyte development at key checkpoints. We re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development. These mechanistic insights can allow better appreciation of the context-dependent roles of Id proteins in cancers and improve considerations for therapy.

Keywords： Id proteins     lymphoma     leukemia     T cells     B cells     tumor suppressor     oncogene    

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Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:

Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 468-477 doi: 10.1007/s11684-015-0419-6

Abstract:

Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathologicalBone marrow (BM) infiltration is more commonly present in mature T-cell lymphoid malignancies comparedstudy, clinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cell lymphoidclinical characteristics may be useful in more effectively stratifying patients with mature T-cell lymphoid

Keywords： mature T-cell lymphoid malignancies     clonal T-cell population     bone marrow infiltration     prognostic factors    

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Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 288-303 doi: 10.1007/s11684-015-0412-0

Abstract: signaling directly or indirectly promotes differentiation of myeloid cells at the expense of that of lymphoid

Keywords： TLR     MyD88     hematopoiesis     bone marrow failure     leukemia     myelodysplastic syndrome    

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Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 31-52 doi: 10.1007/s11684-013-0251-9

Abstract:

Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple roles of Zn: (1) a constructive component of many important enzymes or proteins, (2) a requirement for insulin storage and secretion, (3) a direct or indirect antioxidant action, and (4) an insulin-like action. However, whether there is a clear cause-and-effect relationship of Zn with metabolic syndrome, diabetes, or diabetic complications remains unclear. In fact, it is known that Zn deficiency is a common phenomenon in diabetic patients. Chronic low intake of Zn was associated with the increased risk of diabetes and diabetes also impairs Zn metabolism. Theoretically Zn supplementation should prevent the metabolic syndrome, diabetes, and diabetic complications; however, limited available data are not always supportive of the above notion. Therefore, this review has tried to summarize these pieces of available information, possible mechanisms by which Zn prevents the metabolic syndrome, diabetes, and diabetic complications. In the final part, what are the current issues for Zn supplementation were also discussed.

Keywords： zinc     zinc transporters     metallothionein     diabetes     diabetic complications     insulin resistance     antioxidant    

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post-transplantation cyclophosphamide for allogeneic peripheral stem cell transplantation for adult patients with lymphoid

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 108-115 doi: 10.1007/s11684-019-0730-8

Abstract: Improved survival rate was reported in lymphoid malignancies following PT-Cy strategy compared with myeloidprophylaxis after myeloablative conditioning and T cell-replete peripheral stem cell transplantation in lymphoidA prospective study with additional patients is warranted to confirm the role of PT-Cy in lymphoid malignancy

Keywords： post-transplantation cyclophosphamide     allogeneic hematopoietic stem cell transplantation     lymphoid malignancies    

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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 460-471 doi: 10.1007/s11684-021-0861-6

Abstract: Compared with exercise, LCD might be more efficient for weight loss and glucose homeostasis in people

Keywords： low-carbohydrate diet     obesity     nonalcoholic fatty liver disease     continuous glucose monitoring     mean sensor glucose    

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alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis

Frontiers of Medicine doi: 10.1007/s11684-023-0983-0

Abstract: alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 559-565 doi: 10.1007/s11684-017-0562-3

Abstract: The proliferation potential of Zfyve16KO B-lymphoid cells also significantlyproliferation of T cells, possibly through the TGF-β signaling, but upregulates the proliferation of B-lymphoid

Keywords： Zfyve16     endofin     hematopoiesis     TGF-β     lymphocytes    

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Planetary Homeostasis of Reactive Nitrogen Through Anaerobic Ammonium Oxidation

Guibing Zhu,Bangrui Lan,Shuci Liu,Cameron M. Callbeck,Shanyun Wang,Liping Jiang,Asheesh Kumar Yadav,Jan Vymazal,Mike S. M. Jetten,Ganlin Zhang,Yongguan Zhu,

Engineering doi: 10.1016/j.eng.2023.09.013

Abstract: release of ammonium and N2O in many oxygen-limited situations, assisting in the restoration of the homeostasis

Keywords： biogeochemical N-cycle     oxic–anoxic interface     nature-based solution     biogeoengineering     nitrogen sustainable development    

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Engineered Vasculature for Organ-on-a-Chip Systems Review

Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang, Huayong Yang

Engineering 2022, Volume 9, Issue 2,   Pages 131-147 doi: 10.1016/j.eng.2021.06.020

Abstract:

Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurateThe circulatory system, the most abundant organ in the human body, plays a crucial role in oxygen exchangeThus, it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissueand organ microenvironments and physiological functions.This review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology

Keywords： Organ-on-a-chip     Vasculature     Bioprinting     Tumor-on-a-chip    

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A literature review of perishable medical resource management

Frontiers of Engineering Management   Pages 710-726 doi: 10.1007/s42524-023-0278-9

Abstract: In recent decades, healthcare providers have faced mounting pressure to effectively manage highly perishable and limited medical resources. This article offers a comprehensive review of supply chain management pertaining to such resources, which include transplantable organs and healthcare products. The review encompasses 93 publications from 1990 to 2022, illustrating a discernible upward trajectory in annual publications. The surveyed literature is categorized into three levels: Strategic, tactical, and operational. Key problem attributes and methodologies are analyzed through the assessment of pertinent publications for each problem level. Furthermore, research on service innovation, decision analytics, and supply chain resilience elucidates potential areas for future research.

Keywords： perishable medical resources     organ transplant     healthcare products     decision analytics     operations management    

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: known as a new candidate tumor suppressor gene, is emerging as a sentinel molecule for gauging tissue homeostasis

Keywords： ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

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Piezoelectric pump with flexible venous valves for active cell transmission

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0712-4

Abstract: The development of organ-on-a-chip systems demands high requirements for adequate micro-pump performanceThe proposed pump can help to construct the circulating organ-on-a-chip system, and the simple structuredesign of the micro-pump and providing a reference for the further study of active cell transport in organ-on-a-chip

Keywords： venous valve     flexible venous valve     cell transmission     organ-on-a-chip system     piezoelectric device    

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The relevance of James Lovelock’s research and philosophy to environmental science and academia

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1639-7

Abstract: Not only are the adaptive mechanisms of Gaia central to the conversation of environmental homeostasis

Keywords： independence     Climate change     Electron capture detector     Environmental equilibrium     Global warming     Homeostasis    

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Title Author Date Type Operation

Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Journal Article

Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Journal Article

Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:

Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao

Journal Article

Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Journal Article

Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Journal Article

post-transplantation cyclophosphamide for allogeneic peripheral stem cell transplantation for adult patients with lymphoid

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Journal Article

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized

Journal Article

alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis

Journal Article

Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Journal Article

Planetary Homeostasis of Reactive Nitrogen Through Anaerobic Ammonium Oxidation

Guibing Zhu,Bangrui Lan,Shuci Liu,Cameron M. Callbeck,Shanyun Wang,Liping Jiang,Asheesh Kumar Yadav,Jan Vymazal,Mike S. M. Jetten,Ganlin Zhang,Yongguan Zhu,

Journal Article

Engineered Vasculature for Organ-on-a-Chip Systems

Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang, Huayong Yang

Journal Article

A literature review of perishable medical resource management

Journal Article

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

Piezoelectric pump with flexible venous valves for active cell transmission

Journal Article

The relevance of James Lovelock’s research and philosophy to environmental science and academia

Journal Article